Table 4.

Epigenetic regulation of berberine on tumor.

Type of Regulation	Cell Lines	Mechanism	Reference
DNA methylation	Multiple myeloma	DNMT1↓, DNMT3B↓	Asadi et al., 2018; Riaz et al., 2015; Nardi et al., 2018
		CDKN1A↑, GADD45B↑
		Bax↑, PMAIP1↑
	U266 cells	CCNB1↓, CCND3↓, CCNE1↓
Histone Modification	Human non small cell lung cancer A549	HDAC↓MMP2↓ MMP9↓	Huang et al., 2017
	U266 cells	CBP/P300↑ SIRT3↑	Sun et al., 2017
MicroRNA	Human U266 multiple myeloma cells	miRNA21, Bcl-2↓	Hashiguchi et al., 2017
	Colon cancer	miR-152↓;	Hu et al., 2013
		miR-429↓
		miR-29↓a