Table 3.
Summary of the external computational programs used by the six programs to predict the protein features instrumental to filter or classify PVCs.
Protein feature | Prediction program | NERVE | Vaxign | Jenner-predict | VacSol | Bowman-Heinson |
---|---|---|---|---|---|---|
Subcellular localization | Psortb | X | X | X | X | |
TargetP | X | |||||
Transmembrane domains | HMMTOP | X | X | X | X | |
Pathogenic domains or virulent factors | SPAAN | X | X | |||
Pfam | X | |||||
VFDB | X | |||||
LipoP | X | |||||
Similarity to host proteins | BLASTp against MHCPEP db | X | ||||
BLASTp against RefSeq and Swiss Prot db | X | |||||
OrthoMCL | X | |||||
B-T cell response | NetMhc | X | ||||
Vaxitope | X | |||||
ABCPred | X | |||||
ProPred-I | X | |||||
ProPred | X | |||||
GPS-MBA | X | |||||
PickPocket | X | |||||
Post-translational modification | YinOYang (glycosylation) | X | ||||
NetPhosK (phosphorylation) | X | |||||
ProP (proprotein convertase cleavage) | X |