Table 3.

Summary of the external computational programs used by the six programs to predict the protein features instrumental to filter or classify PVCs.

Protein feature	Prediction program	NERVE	Vaxign	Jenner-predict	VacSol	Bowman-Heinson
Subcellular localization	Psortb	X	X	X	X
	TargetP					X
Transmembrane domains	HMMTOP	X	X	X	X
Pathogenic domains or virulent factors	SPAAN	X	X
	Pfam			X
	VFDB				X
	LipoP					X
Similarity to host proteins	BLASTp against MHCPEP db	X
	BLASTp against RefSeq and Swiss Prot db				X
	OrthoMCL		X
B-T cell response	NetMhc					X
	Vaxitope		X
	ABCPred				X
	ProPred-I				X
	ProPred				X
	GPS-MBA					X
	PickPocket					X
Post-translational modification	YinOYang (glycosylation)					X
	NetPhosK (phosphorylation)					X
	ProP (proprotein convertase cleavage)					X