Table 3.
Summary of the external computational programs used by the six programs to predict the protein features instrumental to filter or classify PVCs.
| Protein feature | Prediction program | NERVE | Vaxign | Jenner-predict | VacSol | Bowman-Heinson |
|---|---|---|---|---|---|---|
| Subcellular localization | Psortb | X | X | X | X | |
| TargetP | X | |||||
| Transmembrane domains | HMMTOP | X | X | X | X | |
| Pathogenic domains or virulent factors | SPAAN | X | X | |||
| Pfam | X | |||||
| VFDB | X | |||||
| LipoP | X | |||||
| Similarity to host proteins | BLASTp against MHCPEP db | X | ||||
| BLASTp against RefSeq and Swiss Prot db | X | |||||
| OrthoMCL | X | |||||
| B-T cell response | NetMhc | X | ||||
| Vaxitope | X | |||||
| ABCPred | X | |||||
| ProPred-I | X | |||||
| ProPred | X | |||||
| GPS-MBA | X | |||||
| PickPocket | X | |||||
| Post-translational modification | YinOYang (glycosylation) | X | ||||
| NetPhosK (phosphorylation) | X | |||||
| ProP (proprotein convertase cleavage) | X |