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. 2019 Feb 14;10:244. doi: 10.3389/fmicb.2019.00244

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Copyright © 2019 Fu, Qin, Zong, Liu, Kang, Zhong and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clavulanic acid biosynthesis is regulated by the TCS CagRS. (A) Schematic overview of the expression profiles of genes involved in CA, G3P and the arginine metabolism pathway. CEA, N²-(2-carboxyethyl)-arginine; DGPC, deoxyguanidino-proclavaminic acid; TCA, tricarboxylic acid cycle. The numbers are the ratios of the comparative expression levels in ΔcagRS compared with the control F613-1, and the data are from the transcriptome and the RT-qPCR assays. Red indicates downregulation, green indicates upregulation, and black indicates no notable change. (B) Model of the TCS CagRS regulatory network of CA biosynthesis.