Table 2.
Clavulanic acid (CA) biosynthesis-associated genes identified as CagR targets by ChIP-seq.
| Gene ID in ATCC 27064 | Gene ID in F613-1 | Biological function | Pathway | -Log10 (p-value) |
|---|---|---|---|---|
| SCLAV_4189(cyp450) | BB341_RS07850 (cyp450) | Cytochrome P450 | Biosynthesis of CA | 3.05595 |
| SCLAV_4191(claR) | BB341_RS07840 (claR) | Transcriptional regulator | CA biosynthesis regulation | 4.0205 |
| SCLAV_0471(avaA2) | BB341_RS25520(avaA2) | Gamma-butyrolactone biosynthesis protein | CA biosynthesis regulation | 2.53812 |
| SCLAV_1147 (pgk) | BB341_RS22330 (pgk) | Phosphoglycerate kinase | Glycolysis | 3.0029 |
| SCLAV_4367 | BB341_RS07030 | Enoyl-CoA hydratase | Fatty acid degradation | 2.33484 |
| SCLAV_0228 | BB341_RS26625 | Acyl-CoA dehydrogenase | Fatty acid degradation | 3.83473 |
| SCLAV_2974(paaH) | BB341_RS03665(paaH) | 3-hydroxybutyryl-CoA dehydrogenase | Fatty acid degradation | 4.78544 |
| SCLAV_1431(glnA3) | BB341_RS20995(glnA3) | Glutamine synthetase | Arginine synthesis | 2.80523 |
The genes listed in this table are limited to those associated with CA biosynthesis.