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. 2019 Feb 21;7:7. doi: 10.1038/s41413-019-0045-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Expression of a gain-of-function mutation of HIF2 in osteoblast precursors inhibits their terminal differentiation in vivo. At the top, dark-field images of in situ hybridization for Col1a1 (a) and Ocn (b) mRNAs of histological sections of HIF2dPA^f/+ and PRX-HIF2dPA^f/+ newborn tibias are shown. Scale bar = 1 mm. At the bottom, bright-field close-up images are provided. Scale bars = 50 μm