Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 20;10:863. doi: 10.1038/s41467-019-08854-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — IFNγ response is strongly induced by the in RV144 vaccine. a Barplot presenting the pathways modulated by the RV144 vaccine two weeks after the last immunization compared to preimmunization. A normalized enrichment score (NES) greater than 0 corresponds to a pathway for which member genes are upregulated in vaccinees. Eleven pathways were significantly modulated after immunization in RV144 vaccinees but not in placebo recipients (DB: Hallmark, GSEA: FDR ≤ 5%). b Sample-enrichment analysis (SLEA) of those 11 pathways followed by clustering revealed that those pathways could be separated into four groups of highly correlated pathways (indicated by the black boxes). The representative pathway of each of the four groups (the most significantly enriched) is indicated in black while the remaining pathways are labeled in gray. c Heatmap presenting the SLEA z-score of each of the 11 pathways among the 40 vaccinees and 10 placebo recipients included in the transcriptomic pilot study at both timepoints investigated (pre: prevaccination, post: 2 weeks after the last immunization). An SLEA z-score greater than 0 corresponds to a pathway for which member genes are up-regulated while an SLEA z-score inferior to 0 corresponds to a pathway with genes downregulated in that sample