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. 2019 Feb 20;10(3):172. doi: 10.1038/s41419-019-1428-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Analysis of miR-185 conservation in different species. b Scheme used to generate miR-185 knockout mice. c Genotyping of transgenic mice by PCR with DNA extracted from mouse tail. Expected band sizes: miR-185 knockout (KO) 512 bp, wild type (WT) 616 bp, heterozygous showed two bands. d Representative real-time PCR result showed endogenous miR-185 expression levels in different tissues of WT and KO mice (n = 3). e Micro-computed tomography (μCT) analysis of 6-week-old WT and KO male mice femur samples (n = 5). Bone volume/total volume (BV/TV), trabecular bone surface/bone volume (BSA/BV), trabecular bone thickness (Tb. Th), trabecular bone number (Tb. N), and trabecular bone space (Tb. Sp). Data were shown as mean ± S.D (**P < 0.01 ***P < 0.001)