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. 2019 Feb 20;9:2358. doi: 10.1038/s41598-019-38865-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations within endocannabinoid and endocannabinoid-like lipid levels and with parameters of disease severity. (a) Anandamide (AEA) levels (ng/ml) highly correlate with levels of palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) (ng/ml) in plasma samples of controls and in patients with ulcerative colitis (UC) and colorectal cancer (CRC). (b) OEA (ng/ml) highly correlates with severity of CD (Harvey Bradshaw Index, HBI) but not with severity of UC (Mayo score). (c) 2-arachidonoylglycerol (2-AG) correlates negatively with HBI in CD, but not with Mayo score in UC. N = 12–17; Pearson correlation; p < 0.05 considered significant.