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. 2019 Feb 20;9:2358. doi: 10.1038/s41598-019-38865-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Localization of receptors of GPR55 and CB₂ in IBD and CRC patients. ISH staining of GPR55 mRNA (a–d) and CB₂ mRNA (e–h) in colonic mucosal biopsies of control subjects (a,e), patients with Crohn’s disease (CD) (b,f), ulcerative colitis (UC) (c,g), and colorectal cancer (CRC) (d,h). Images are representative for three individuals/cohort. Arrows point at representative DAB staining of GPR55 and CB₂ mRNA. Calibration bars: 50 µm (a–d); 20 µm (e–h).