Table 6.
The PDBSum analysis of wild-type ABL structure with mutated ABL structures.
| BCR-ABL Structure | Sheets | Beta alpha beta units | Beta heparins | Beta bulges | Strands | Helices | Helix-Helix interactions | Beta turns | Gamma turns |
|---|---|---|---|---|---|---|---|---|---|
| Wild-type | 7 | 1 | 11 | 9 | 23 | 19 | 16 | 48 | 5 |
| p.(Glu281*) | 4 | 1 | 8 | 7 | 15 | 5 | 0 | 29 | 5 |
| p.(Tyr393*) | 6 | 1 | 10 | 9 | 21 | 10 | 2 | 38 | 6 |
| p.(Asp381Asn) | 7 | 1 | 11 | 9 | 23 | 18 | 16 | 46 | 6 |
| p.(Glu373Asp) | 7 | 1 | 11 | 9 | 23 | 18 | 16 | 46 | 7 |
| p.(Phe317Leu) | 7 | 1 | 11 | 9 | 23 | 18 | 16 | 47 | 4 |
| p.(Gly250Glu) | 7 | 1 | 11 | 9 | 23 | 19 | 16 | 48 | 5 |
| p.(Leu301Ile) | 7 | 1 | 11 | 9 | 23 | 18 | 16 | 46 | 6 |
| p.(Met351Thr) | 7 | 1 | 11 | 9 | 23 | 18 | 16 | 47 | 6 |
| p.(Thr315Ile) | 7 | 1 | 11 | 9 | 23 | 18 | 16 | 47 | 4 |
| p.(Val256Gly) | 7 | 1 | 11 | 9 | 23 | 17 | 16 | 49 | 5 |
| p.(Tyr253His) | 7 | 1 | 11 | 9 | 23 | 19 | 16 | 47 | 5 |
| p.(Tyr320His) | 7 | 1 | 11 | 9 | 23 | 18 | 16 | 46 | 8 |