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. 2019 Feb 20;9:2399. doi: 10.1038/s41598-019-38643-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cxcr4b transcriptomic signature in zebrafish neutrophils. (A) Heatmap showing up- and down-regulated genes in cxcr4b^−/− neutrophils compared to cxcr4b^+/+ neutrophils. 61% is the percentage of up-regulated genes, whereas 39% is the percentage of down-regulated genes. Genes involved in focal adhesion, ECM-Receptor interaction and axon guidance are up-regulated. Percentages of up- or down-regulation are calculated based on the total number of genes left after a cutoff of p < 0.05 in both DESeq and edgeR (neutrophil dataset: from n = 21517 to n = 508). Before the analysis, 107 genes were manually removed in the neutrophil dataset due to high variation among the triplicates. An alternative analysis method using DESeq2 paired confirmed the affected pathways (Table 2).

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