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. 2019 Feb 20;9:2350. doi: 10.1038/s41598-019-39487-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibitory effect of the 25 hit lead candidates on HDAC and molecular docking results of the four active lead candidates. (A) The HDAC activities ratio of the hit lead candidates. The positive control was represent by blue, the inhibitor control was represent by red, the hit compounds was represent by green. The results are the mean ± S.D. of at least three independent experiments. Two-tailed student’s t-test was performed between HDACi vs. control, *P < 0.05, **P < 0.01. (B) Docking analysis of ZINC24469384, ZINC08671161, ZINC48302525 and ZINC080113624 to HDAC and a yellow dotted line shows the hydrogen bond.