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. 2019 Feb 20;9:2350. doi: 10.1038/s41598-019-39487-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ZINC24469384 can induces apoptosis and cell cycle arrest in HepG2 cells. (A,B) Assessment of the dose dependent and time dependent effect of ZINC24469384 on acetylation histone H3 in HepG2 cells after treatment. H3 was used as an internal control. (C,E) HepG2 and Hep3B cells were treated with 40 μM control (DMSO) or ZINC24469384 for 24 h, 36 h and 48 h. Then the cells were stained with Annexin V⁺/PI⁺ or PI and using flow cytometer to analysis the percentage of apoptosis cells and cell cycle phase distribution. (D,F) HepG2 cells were treated with μM DMSO for 48 h or equivoluminal ZINC24469384 for 12 h, 24 h, 36 h and 48 h, respectively. Cells were collected and analysis the expression of apoptosis marker (Bax and Bcl-2) and cell cycle arrest markers (CyclinA and CyclinB) using Western Blot. GAPDH was used as an internal control.