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. 2019 Feb 20;9:2372. doi: 10.1038/s41598-019-38870-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IFN-γ and TNF-α impair the production of infectious viruses in LECs. Human primary cells (LECs, HUVECs, TIME) were infected with rKSHV.219 at MOI = 3 in the absence/presence of IFN-γ (A) or TNF-α (B) (0 to 5000 units/ml) for the indicated time period. Infectious viruses in the culture supernatant were determined. The means ± SEM of three independent experiments is plotted. *P < 0.01 by one-way ANOVA Tukey Method.