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. 2019 Feb 20;9:2372. doi: 10.1038/s41598-019-38870-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IFN-γ inhibits KSHV lytic replication in a time- and dose-dependent manner. iSLK.219 cells were induced without or with Dox (0.2 μg/ml), and IFN-γ (0, 20, or 200 units/ml) was added into the culture at the indicated time. Infectious virus titer in the culture supernatant was determined at 72 hr post-induction and normalized to the medium-treated control. The means ± SEM of triplicated samples is plotted. One representative result is shown from 3 independent experiments. *P < 0.01 by one-way ANOVA Tukey method.