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. 2019 Feb 20;9:2430. doi: 10.1038/s41598-019-38852-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HC-030031 blocked ASP7663-induced mechanical hypersensitivity in C57BL/6 mice. Mechanical sensitivity was measured in C57BL/6 mice pre- and post-drug administration (n = 4 per treatment) in response to von Frey filament stimulation. Systemic administration of HC-030031 (100 mg/kg, p.o.) blocked mechanical hypersensitivity induced by ASP7663 (1 mg/kg, i.p.). (Two-way ANOVA, Effect of pre-drug x post-drug: F_1,18 = 1.522, p = 0.2332; Group effects: F_2,18 = 4.426, p = 0.0273; After Bonferroni’s multiple comparison, Pre-ASP7663 vs. Post-ASP7663: *p = 0.0034).