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. 2019 Feb 20;10:856. doi: 10.1038/s41467-019-08775-0

Table 1.

Clinical and laboratory characteristics of case-patients

Characteristic HbAA HbAS P value
All admissions (n, %) 16,502 (90.21) 1791 (9.79) n/a
Median age (IQR; months) 17.5 (7.2–35.4) 14.3 (5.2–31.8) 0.0001
Mean WAZ (95% CI) −1.69 (−1.71, −1.67) −1.59 (−1.66, −1.52) 0.0075
Mean HAZ (95% CI) −1.33 (−1.36, −1.30) −1.30 (−1.39, −1.22) 0.613
Mean parasite density (95% CI; parasites/mcl)a 28,597 (27,015–30,270) 10,002 (7686–13,015) <0.0001
Mean hemoglobin (95% CI g/L) 91.4 (90.9–91.9) 98.0 (96.6–99.3) <0.0001
Mean MCV (95% CI) 74.1 (73.9–74.3) 72.5 (71.8–73.2) <0.0001
Median WBC (IQR; ×109/mcl) 12.0 (8.7–16.7) 12.9 (9.1–17.7) <0.0001
Median platelets (IQR; ×106/L) 273 (134–442) 373 (227–528) <0.0001

The data summarized reflect the clinical and laboratory features of hospital-admitted case-patients only, stratified by HbS genotype. P values estimated by use of Student’s t test, χ2, or Mann–Whitney tests as appropriate in comparison to HbAA children

WAZ weight-for-age Z-score, HAZ height-for-age Z-score

aGeometric mean densities among children with positive slides (7222 (43.8%) of HbAA and 384 (21.4%) of HbAS children)