Table 2.
Distribution of clinical syndromes and outcomes among case-children
| Syndrome | HbAA (N = 16,502) | HbAS (N = 1791) |
|---|---|---|
| Clinical syndromes | ||
| Neonatal conditions | 1615 (9.8) | 224 (12.5) |
| Malaria | 5308 (32.2) | 252 (14.1) |
| Severe malaria | 838 (5.1) | 20 (1.1) |
| Severe pneumonia | 446 (2.7) | 54 (3.0) |
| Very severe pneumonia | 9760 (59.1) | 1073 (59.9) |
| Meningitis/encephalitis | 2779 (16.8) | 294 (16.2) |
| Severe malnutrition | 1428 (8.7) | 166 (9.3) |
| Gastroenteritis | 3038 (18.4) | 378 (21.1) |
| Transfused | 1543 (9.4) | 80 (4.5) |
| Other | 1069 (6.5) | 204 (11.4) |
| Laboratory based syndromes | ||
| Bacteremia | 854 (5.2) | 98 (5.5) |
| Malaria blood film positive | 7222 (43.8) | 384 (21.4) |
| Malaria blood film negative | 9280 (56.2) | 1407 (78.6) |
| Severe anemia | 1389 (8.6) | 80 (4.5) |
| Outcome | ||
| Median duration of admission (IQR; days) | 3 (2, 5) | 3 (2, 6) |
| Death (n; %) | 974 (5.9) | 113 (6.3) |
The data summarized reflect the clinical and laboratory features of hospital-admitted case-patients only, stratified by HbS genotype. Some children contribute data to more than one row. Definitions can be found in the text. Figures in parentheses denote the proportion of admissions with specific diagnoses within each genotypic group