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. 2019 Jan 10;116(4):610–620. doi: 10.1016/j.bpj.2019.01.005

Figure 2.

Figure 2

Cd2+ promotes an interdomain interaction wild-type PrP at pH 6.0. (A) A selected region of the 1H-15N HSQC of wild-type PrP in the absence of metal (black) and in the presence of 1.0 mM of Cd2+ (blue). (B) A bar graph of I/Io for residues 90–23 of PrPC in the presence of Cd2+. (C and D) Surface and ribbon plots, respectively, of C-terminal residues affected by the presence of Cd2+ (coordinates from Protein Data Bank (PDB): 1XYX). Affected residues are noted specifically on the ribbon diagram.