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. 2019 Feb 21;7:6. doi: 10.1038/s41413-018-0037-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Specificity of Cre activity in osteocytes and dendritic processes in Sost ER^T2 Cre mice. In bone, the tdTomato signal showed strong specificity for osteocytes in Sost ER^T2 Cre/tdTomato mice treated with tamoxifen, as no signal was seen in osteoblasts, muscle or bone marrow. a Epifluorescence microscopy in the femur at 4x magnification. Higher power b (20 × ) and c (100 × ) confocal images are shown of the lacunocanalicular network in the femur of these mice showing specific targeting of Cre activity to osteocytes and also showing that these mice may be useful to analyze the osteocyte network as well as their dendrites and connections. TdTomato is shown in red and DAPI signal is in blue