Table 3.

Summary of tests for replication for two novel loci on chromosome 8 with p-values < 10⁻⁶ in the CAAPA meta-analysis

SNP	Ethnicity	Study	Number non-asthmatics	Number asthmatics	p-value	Effect direction
rs13277810	African ancestry	CAAPA	7 009	7 645	3.20E−08	+
	African American	CARDIA	109	860	1.68E−01	+
	African American	MESA	200	1437	5.44E−01	−
	African American	ARIC	89	1636	5.24E−01	−
	African American	BioMe	391	1550	1.07E−01	−
	Hispanic	BioMe	519	1775	7.15E−04	+
rs13269769a	European	TAGC	19,954	107,715	9.55E−02b	−
rs114647118	African ancestry	CAAPA	7 009	7 645	2.70E−07	−
	African American	CARDIA	109	862	5.61E−02	+
	African American	MESA	200	1440	4.62E−01	−
	African American	ARIC	89	1638	7.18E−01	−

rs13277810 is a common variant that reached genome-wide significance, and rs114647118 is a low frequency variant with MR-MEGA association p-value < 10⁻⁶. rs13277810 was not available in the TAGC meta-analysis summary statistics, but rs13269769, a SNP that has high LD with rs13277810 in the 1000 Genomes Project Europeans, was available. The rs114647118 association had low imputation quality in BioMe, and was not included in the TAGC meta-analysis summary statistic dataset. Effect direction is defined in terms of the minor allele. The CAAPA discovery associations are highlighted in bold font

^ar² with rs13277810 in TGP EUR = 0.994

^bFixed-effect p-value