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. 2019 Feb 20;9:2410. doi: 10.1038/s41598-019-38634-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Viability of OC-k3 and HEI-OC1 cell cultures following AG treatments. Selected AGs were applied to the OC-k3 and HEI-OC1 otic cell lines at 2 mM (a) and 5 mM (b). After 48-h, the viability of the cells were determined using the MTT test, comparing the treated cells to the control cells (100%). Data are presented as means ± SD. *p < 0.05; **p < 0.01 (two-tailed unpaired Student’s t-tests used to compare each treatment to controls). (a) 2 mM AGs, OC-k3 cells: GM C1a, p = 0.3; Apra, p = 0.87; GM, p = 0.00000; Paro, p = 0.8; Neo, p = 0.016; (a) 2 mM AGs, HEI-OC1 cells: GM C1a, p = 0.01; Apra, p = 0.18; GM, p = 0.016; Paro, p = 0.051; Neo, p = 1.99E-5; (b) 5 mM AGs, OC-k3 cells: GM C1a, p = 0.003; Apra, p = 0.009; GM, p = 0.01; Paro, p = 0.043; Neo, p = 0.0005; (b) 5 mM AGs, HEI-OC1 cells: GM C1a, p = 0.006; Apra, p = 3.3E-6; GM, p = 0.001; Paro, p = 0.0001; Neo, p = 5.5E-5). Abbreviations: AG, aminoglycoside; Apra, apramycin; GM, gentamicin; GM C1a, gentamicin C1a; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; Neo, neomycin; Paro, paromomycin.