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. 2019 Feb 20;9:2410. doi: 10.1038/s41598-019-38634-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AG-induced effects on SP-, CAP- and SP/CAP amplitudes. (a) SP and CAP measurements in the control group (left) and the AG-treated group, before and 21 days after the application of 60 mg/mL GM (right), recorded at 80 dB sound pressure level of 22.6 kHz. (b) SP amplitude ratio among six groups on day 21. (c) SP/CAP amplitude ratio among seven groups (before application in all groups (n = 36), control and those receiving AGs). (d) Correlation between SP/ CAP amplitude ratio and synaptic ribbon number in the groups of animals treated with 60 mg/mL AGs (n = 32). Data are means ± SD. *p < 0.05; **p < 0.01; ***p < 0.001 (one-way ANOVA with Tukey’s multiple comparison tests). (b) p = 0.0001. (c) p = 0.846). Abbreviations: CAP, compound action potential; Apra, apramycin; GM, gentamicin; GM C1a, gentamicin C1a; Neo, neomycin; SP, Summating potential; Paro, paromomycin.