Table 1.
Univariate analysis of characteristics at first diagnosis and pretreatment blood parameters
| 60 included patients | 25 patients achieving first remission | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | 3‐y EFS (95% CI) | P value | 3‐y OS (95% CI) | P value | N (%) | 3‐y EFS (95% CI) | P value | 3‐y OS (95% CI) | P value | |
| Gender | ||||||||||
| Female | 11 (18) | 27.3 ± 26.3 | 0.327 | 27.3 ± 26.3 | 0.802 | 6 (24) | 50.0 ± 40.0 | 0.599 | 50.0 ± 40.0 | 0.471 |
| Male | 49 (82) | 7.7 ± 7.6 | 31.9 ± 13.5 | 19 (76) | 19.7 ± 18.6 | 60.2 ± 23.1 | ||||
| Age [years] | ||||||||||
| ≤10 | 9 (15) | 22.2 ± 27.2 | 0.201 | 64.8 ± 32.3 | 0.175 | 5 (20) | 40.0 ± 42.9 | 0.494 | 50.0 ± 69.4 | 0.225 |
| 10‐21 | 44 (73) | 10.9 ± 9.4 | 26.7 ± 13.1 | 18 (72) | 26.7 ± 21.0 | 48.9 ± 23.5 | ||||
| ≥21 | 7 (12) | 0 | 16.7 ± 29.8 | 2 (8) | 0 | 50.0 ± 69.4 | ||||
| Site of primary | ||||||||||
| Abdominal | 56 (93) | 6.7 ± 6.7 | 0.01 | 27.7 ± 12.2 | 0.058 | 21 (84) | 17.9 ± 17.1 | 0.057 | 54.0 ± 22.3 | 0.31 |
| Extra‐abdominal | 4 (7) | 75.0 ± 42.5 | 75.0 ± 42.5 | 4 (16) | 75.0 ± 42.5 | 75.0 ± 42.5 | ||||
| Size of primary | ||||||||||
| <10 cm | 18 (30) | 16.7 ± 17.2 | 0.145 | 35.4 ± 23.3 | 0.59 | 7 (28) | 42.9 ± 36.7 | 0.138 | 83.3 ± 29.8 | 0.236 |
| ≥10 cm | 40 (67) | 9.4 ± 9.4 | 30.3 ± 14.7 | 18 (72) | 20.8 ± 19.4 | 48.5 ± 23.7 | ||||
| No information | 2 (3) | |||||||||
| Tumor distribution | ||||||||||
| Localizeda | 6 (20) | 66.7 ± 37.6 | 0.004 | 83.3 ± 29.8 | 0.001 | 5 (20) | 80.0 ± 35.1 | 0.005 | 100% | 0.015 |
| Regionally dissem. | 16 (27) | 6.3 ± 12.0 | 33.5 ± 23.9 | 9 (36) | 11.1 ± 20.6 | 55.6 ± 32.5 | ||||
| Extrap. metastases | 38 (63) | 5.3 ± 7.1 | 22.1 ± 13.3 | 11 (44) | 18.2 ± 22.7 | 40.4 ± 30.4 | ||||
| Extraperitoneal metastases in single or multiple organ | ||||||||||
| No distant mets | 22 (37) | 22.7 ± 17.4 | 0.134 | 47.7 ± 21.4 | 0.004 | 14 (56) | 35.7 ± 25.1 | 0.488 | 71.4 ± 23.7 | 0.038 |
| Single organ mets | 16 (27) | 12.5 ± 16.3 | 27.5 ± 22.5 | 6 (24) | 33.3 ± 37.6 | 60.0 ± 42.9 | ||||
| Multiple organ mets | 22 (37) | 0% | 18.2 ± 16.1 | 5 (20) | 0% | 20.2 ± 35.1 | ||||
| Effusion | ||||||||||
| No effusion | 37 (62) | 13.0 ± 11.0 | 0.005 | 39.9 ± 16.5 | <0.001 | 18 (72) | 26.7 ± 21.0 | 0.347 | 57.6 ± 24.1 | 0.008 |
| Ascites | 14 (13) | 14.3 ± 18.4 | 26.8 ± 24.1 | 5 (20) | 40.0 ± 42.9 | 80.0 ± 35.1 | ||||
| Pleural effusion | 3 (5) | 0% | 0% | 2 (8) | 0% | 0% | ||||
| Ascites + pleural eff | 6 (10) | 0% | 0% | 0 (0) | ||||||
| Venous thrombosis | ||||||||||
| No | 53 (88) | 12.6 ± 9.2 | <0.001 | 34.7 ± 13.3 | <0.001 | 23 (92) | 29.0 ± 19.2 | <0.001 | 61.8 ± 21.0 | <0.001 |
| Yes | 4 (7) | 0% | 0% | 2 (8) | 0% | 0% | ||||
| No information | 3 (5) | |||||||||
| Elevation of CRP | ||||||||||
| No | 17 (28) | 29.4 ± 21.8 | 0.002 | 51.8 ± 24.3 | 0.009 | 10 (40) | 50.0 ± 31.0 | 0.011 | 78.8 ± 26.3 | 0.052 |
| Yes | 37 (62) | 4.1 ± 7.1 | 25.6 ± 14.9 | 15 (60) | 10.0 ± 17.2 | 41.3 ± 26.7 | ||||
| No information | 6 (10) | |||||||||
| Thrombocytes > 350/nL | ||||||||||
| No | 40 (67) | 14.6 ± 11.2 | 0.318 | 32.8 ± 14.9 | 0.588 | 17 (68) | 34.3 ± 23.1 | 0.117 | 63.3 ± 23.5 | 0.229 |
| Yes | 16 (27) | 6.3 ± 12.0 | 34.4 ± 24.1 | 8 (32) | 12.5 ± 22.9 | 43.8 ± 36.8 | ||||
| No information | 4 (6) | |||||||||
| Neutrophil‐to‐lymphocyte ratio | ||||||||||
| <median | 24 (40) | 15.4 ± 13.9 | 0.379 | 41.2 ± 20.0 | 0.124 | 11 (44) | 22.2 ± 25.1 | 0.525 | 68.6 ± 23.7 | 0.826 |
| >median | 26 (43) | 11.1 ± 13.3 | 27.8 ± 18.4 | 12 (48) | 36.4 ± 28.4 | 56.3 ± 29.0 | ||||
| No information | 10 (17) | 2 (8) | ||||||||
| Platelet‐to‐lymphocyte ratio | ||||||||||
| <median | 27 (45) | 18.5 ± 14.7 | 0.266 | 35.0 ± 18.4 | 0.356 | 13 (52) | 25.0 ± 24.5 | 0.715 | 51.5 ± 31.0 | 0.781 |
| >median | 27 (45) | 11.1 ± 11.8 | 33.6 ± 18.6 | 12 (48) | 28.8 ± 25.7 | 61.5 ± 26.5 | ||||
| No information | 6 (10) | |||||||||
P values are printed in italics, significant P values are bold (P < 0.05).
a
All with evidence of EWSR1‐WT1 fusion transcript