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. 2019 Jan 11;116(4):725–740. doi: 10.1016/j.bpj.2019.01.007

Figure 4.

Figure 4

FEX-induced calcium waves require GPCR/Gαq signaling. (A–D) Montages from ex vivo time-lapse videos and (A′–D′) kymographs of the corresponding time-lapse videos are shown. The genotypes of the wing discs are indicated on the bottom left. We observed ICWs in (A) and no Ca2+ signaling activity in (B–D). The cross indicates the orientation of the wing disc (Videos S10, S11, S12, and S13). The red arrows indicate single-cell spikes. Position and timescale bars, 25 μm and 15 min. White dotted line represents the pouch boundary. Red line represents the x-y position of the kymograph. The RNAi lines are as follows: GαqRNAi, BL#36775; IP3RRNAi, BL#25937; and Plc21CRNAi, BL#31719. To see this figure in color, go online.