Figure 4.

Letrozole (20 μg/d, p.o.) exerts sex-specific reduction in thermoregulation during thermal challenge. A, Facial temperature was measured via thermal camera during a 20 min thermal challenge. Representative images obtained 5 min and 20 min into the challenge are shown, along with the temperature reading. Percentage change in temperature (°F) from the first minutes of the thermal challenge was plotted over time for females (B; vehicle: n = 2; letrozole: n = 4) and males (C; vehicle: n = 5, letrozole: n = 4). Letrozole treatment resulted in greater elevation in temperature across time for females only (p < 0.001). Error bars indicate SEM.