Figure 5.

IE of CA1 pyramidal neurons is attenuated by 4 weeks of letrozole treatment (20 μg/d, p.o.). *p < 0.05 on all 4 measures. This is observed across 4 measures. A, Firing frequency (Hz) is attenuated as a function of injected current from letrozole-treated cells (n = 14) relative to vehicle (n = 15). This shift in excitability was also related to changes in spontaneous activity by letrozole treatment, as indicated by (B) greater AHP amplitude (AHP; mV), (C) lower RMP (mV), and (D) lower spontaneous spike rate (Hz). Error bars indicate SEM.