Figure 6.

Single acute administration of l-DOPA and bath perfusion of NAc slices with DA restore the decrease in NMDA/AMPA ratio in NAc shell MSNs from EtOH-withdrawn rats. a, Representative EPSCs mediated by NMDA and AMPA receptors recorded in single MSNs clamped at −70 mV (for AMPA) and +40 mV (for NMDAR in the presence of NBQX 5 μm) from the different experimental groups. b, The graph summarizes the NMDAR/AMPAR ratio obtained from MSNs of the different groups. c, Scatter graph illustrating the distribution of individual data averaged in a and b. The number of cells analyzed is indicated in each graph bar and were obtained from five animals per group. ***p = 0.0001.