Figure 7.

The selective antagonist of D1 but not D2 receptors prevents the restoring effect of DA on LTD levels in EtOH-WDL (12 h) rats. NAc slices of EtOH-WDL rats were bath-perfused with DA (10 μm), in the absence or presence of SCH23390 (10 μm) or sulpiride (10 μm), for 5 min prior LFS paired with depolarization (−50 mV). a, b, Scatter plot graph of the changes in EPSC amplitude with data expressed as percentage of baseline. c, The scatter graph illustrates the degree of LTD, as in graphs a and b, and were obtained from five animals. The number of cells analyzed is indicated for each experimental group. ***p = 0.0006.