Fig. 1.

Schematic of the PBPK model developed to characterize the whole-body disposition of T cells in mice. Tissues are arranged and connected in an anatomical manner by blood flow (black sold lines) and lymph flow (gray dotted lines). The red arrow shows the elimination process via lungs, and blue arrows show the transmigration process in each tissue. The tissue compartments are color coded as follows: red is the whole-blood compartment; yellow compartments are lymph node compartments; purple compartments are tissues emptying blood into the liver compartment; blue is the liver compartment that receives the blood from the hepatic artery and hepatic portal vein (i.e., gut compartments); teal compartments are tissues obtaining blood directly from the whole-blood compartment and draining lymph directly into the lymph node compartment; green compartments are tissues with lymphatic fluid draining into two lymph nodes (TDLN and IGLN); and pink is the tumor compartment with lymphatic fluid draining into the tumor-draining lymph node. V denotes a vascular subcompartment, and EV denotes an extravascular subcompartment.