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. 2019 Feb 14;10:111. doi: 10.3389/fneur.2019.00111

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Copyright © 2019 Jeziorska, Atkinson, Kass-Iliyya, Javed, Kobylecki, Gosal, Marshall, Silverdale and Malik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphic representation of nerve fiber measurement in healthy control subjects and patients with PD. Box and whisker plot showing mean, min and max values for IENFD (A), MAL (B), IETNFL/Area (C), and IETNFL/Length (D). Two-tailed unpaired Mann-Whitney rank test was used to compare means between control and PD nerve fiber measurements. P-value and effect size (d) shown (d > 0.5 = medium effect; over 1.0 = large effect). IENFD, intraepidermal nerve fiber density; MAL, mean axonal length; IETNFL, intraepidermal total nerve fiber length.