Fig. 7.

Example of MMIS identifying focal severe dysplasia that would not otherwise have been identified. (a) and (b) WL and AF images of lesion. Two clinical regions were outlined (green). A biopsy was not clinically indicated. (c) and (d) WL and AF images including heat map overlay. An additional suspicious region based on the heat map was outlined (red). (e) and (f) WL and AF images, with HRME sites indicated (white dots). (g) and (h) HRME images acquired from the sites indicated in panels (e) and (f). A biopsy was acquired at site 2 based on the MMIS results and revealed moderate-to-focal severe dysplasia.