Table 2.
Baseline and follow-up characteristics of six primary hyperaldosteronism patients
| Baseline | FUP | P-value | |
|---|---|---|---|
| Age (years) | 55 (48, 61) | 56 (49, 62) | 0.014 |
| Male, n (%) | 5 (83%) | ||
| Body mass index (kg/m2) | 31.6 (24.5, 36.4) | 29.8 (25.8, 34.7) | 0.116 |
| Mean systolic 24 h ABPM (mmHg) | 158 (138, 164) | 132 (127, 163) | 0.027 |
| Mean diastolic 24 h ABPM (mmHg) | 95 (89, 97) | 83 (80, 94) | 0.075 |
| Heart rate (b.p.m.) | 72 (67, 77) | 66 (61, 73) | 0.080 |
| Aldosterone (ng/L) | 265 (156, 445) | 285 (85, 338) | 0.249 |
| Renin (ng/L) | 4.0 (2.3, 7.1) | 4.5 (2.5, 10.6) | 0.753 |
| ARR | 70.4 (52.9, 89.4) | 40.7 (19.3, 76.2) | 0.249 |
| Serum sodium (mmol/L) | 142 (141, 145) | 142 (142, 143) | 0.891 |
| Serum potassium (mmol/L) | 3.9 (3.4, 4.0) | 4.4 (3.5, 4.5) | 0.027 |
| Creatinine (µmol/L) | 76.0 (63.6, 95.5) | 81.4 (69.9, 99.9) | 0.046 |
| LVEF (%) | 55 (43, 61) | 53 (45, 59) | 0.686 |
| LVM (g) | 171 (124, 240) | 184 (121, 188) | 0.500 |
| LVM index (g/m2) | 71 (63, 120) | 74 (62, 95) | 0.345 |
| Myocardial rSSI | 0.31 (0.27, 0.33) | 0.27 (0.22, 0.30) | 0.028 |
| Calf muscle rSSI | 0.19 (0.16, 0.24) | 0.15 (0.12, 0.17) | 0.046 |
| Skin rSSI | 0.28 (0.23, 0.35) | 0.21 (0.17, 0.23) | 0.028 |
Data are median (quartiles). Paired group comparisons were done with Wilcoxon signed rank test.
ARR, aldosterone-renin-ratio; LVEF, left ventricular ejection fraction; LVM, left ventricular mass; rSSI, relative sodium signal intensity.