Figure 1.

The effect of study compound on ex vivo platelet activation. Extra-corporeal administration of JNJ-9375 inhibited thrombin-simulated (A) p-selectin expression and (B) platelet-monocyte aggregates in a dose-dependent manner but had no effect on ADP activity. Data shown are the adjusted means (±95% confidence intervals) and individual points. Statistical comparisons (Least Significance Difference test) vs. placebo are represented above each plot: *P < 0.05, **P < 0.01, ***P < 0.001. ADP, adenosine diphosphate; GMFI, geometric mean fluorescent intensity; PMA, platelet-monocyte aggregates.