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. 2019 Feb 1;22:101133. doi: 10.1016/j.redox.2019.101133

Fig. 2.

Fig. 2

The effects of FGF21 against neuron apoptosis and tau pathology in Aβ25–35-induced cell and rat models. (A) Effect of FGF21 against Aβ25–35-induced neuronal apoptosis in rats’ hippocampus was evaluated by TUNEL assay. Magnified views of the boxed areas in the upper images (Scale bar, 200 µm) were shown in the lower row of images (Scale bar, 50 µm). (B) The levels of Thr181-phosphorylated tau, Thr205-phosphorylated tau, total tau in rats’ hippocampus were measured by western blotting. (C) Effect of Aβ25–35 on SH-SY5Y cell viability. (D) Neuroprotective effect of FGF21 against Aβ25–35-induced decline in SH-SY5Y cell viability. (E) Effect of FGF21 against Aβ25–35-induced apoptosis of SH-SY5Y cells. (F) The levels of Thr181-phosphorylated tau, Thr205-phosphorylated tau, total tau in SH-SY5Y cells were measured by western blotting. All experiments were repeated at least three times. #P < 0.05, ##P < 0.01 and ###P < 0.001 compared with the control group; * P < 0.05, * * P < 0.01 and * ** P < 0.001 compared with the Aβ25–35 group.