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. 2019 Feb 1;22:101133. doi: 10.1016/j.redox.2019.101133

Fig. 3.

Fig. 3

The neuroprotective effects of FGF21 against mitochondrial oxidative damage pathology in vivo and in vitro. (A) Effect of FGF21 on Aβ25–35-induced morphologic changes of mitochondria in SH-SY5Y cells (Left column: scale bar, 5 µm; right column: scale bar, 2 µm). (B) Effect of FGF21 on Aβ25–35-induced excessive production of ROS in SH-SY5Y cells. (C) Effects of Aβ25–35 and FGF21 on the expression levels of Bcl-2, Bax, cleaved caspase-3 in SH-SY5Y cells. (D) The levels of 8-OHdG in rats’ hippocampus under different treatments (Upper column: scale bar, 200 µm; Lower column: scale bar, 50 µm). (E) Effects of Aβ25–35 and FGF21 on the expression levels of Bcl-2, Bax, cleaved caspase-3 in rats’ hippocampus. All experiments were repeated at least three times. #P < 0.05, ##P < 0.01 and ###P < 0.001 compared with the control group; * P < 0.05 and * * P < 0.01 compared with the Aβ25–35 group.