Figure 3.

Chemical Structure and Pharmacokinetics of Lead Lipids

(A) Chemical structures and pK_a of MC3 and novel lipids. (B–D) Lipid concentration (nanograms per gram) after IM administration of modified mRNA encoding luciferase formulated in LNPs containing lipid H (green circles), lipid M (orange squares), lipid P (purple diamonds), lipid Q (tan inverted triangles), and lipid N (yellow hexagons) in (B) muscle, (C) liver, and (D) spleen up to 48 h post-injection (n = 3 per group per time point).