Table 2.
Tissue Vector Genomes
| Tissues (Vector Genomes/μg gDNA) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Mean (SD) | ||||||||
| Serotype-Route | Right Upper Quadriceps (Dosed Limb) | Right Lower Quadriceps (Dosed Limb) | Right Calf (Dosed Limb) | Right Inguinal Lymph Node (Dosed Limb) | Liver | Left Quadriceps (Undosed Limb) | Left Calf (Undosed Limb) | Left Inguinal Lymph Node (Undosed Limb) |
| AAV1-IM | 498,778 (281,500) | 574,208 (562,329) | 1,599,935 (1,115,968) | 2,532,248 (1,319,764) | 376,475 (387,624) | 9,878 (11,388) | 993 (1,118) | 37,998 (30,675) |
| AAV1-IAPD | 44,150 (37,218) | 129,055 (127,706) | 22,530 (18,723) | 368,133 (111,128) | 1,192,300 (284,074) | 3,008 (2,120) | 9,150 (5,185) | 35,348 (25,648) |
| AAV8-IAPD | 86,205 (91,689) | 70,038 (25,065) | 16,885 (8,792) | 293,298 (103,261) | 2,878,100 (1,665,077) | 3,028 (2,099) | 4,253 (2,648) | 55,638 (47,087) |
| AAV1-VLP | 10,188 (8,071) | 9,045 (5,069) | 783,635 (87,715) | 2,213,788 (90,284) | 1,961,980 (470,336) | 13,040 (11,487) | 9,025 (6,956) | 92,483 (39,652) |
| AAV8-VLP | 1,775 (526) | 203,595 (121,972) | 239,328 (84,476) | 980,443 (19,295) | 6,534,063 (5,428,745) | 2,070 (319) | 5,353 (4,253) | 131,755 (–) |
IM, intramuscular; IAPD, intra-arterial push and dwell; VLP, venous limb perfusion.