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Changes in kidney function and injury markers with the standard-dosing regimen of cisplatin (0 or 25 mg/kg once) in 8- and 40-wk-old male FVB mice. A: blood urea nitrogen (BUN) in plasma. B: neutrophil gelatinase-associated lipocalin (NGAL) in urine. C: kidney injury molecule-1 (Kim-1) mRNA in kidney cortex measured by real-time quantitative RT-PCR. Values are means ± SE; n = 5–10. *P < 0.05, ****P < 0.0001 (by 2-way ANOVA followed by Tukey’s post test).
