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Changes in kidney function and injury markers with the repeated-dosing regimen of cisplatin (0 or 7 mg/kg once a week for 4 wk) in 8- and 40-wk-old male FVB mice. A: blood urea nitrogen (BUN) in plasma. B: neutrophil gelatinase-associated lipocalin (NGAL) in urine. C: kidney injury molecule-1 (Kim-1) in kidney cortex measured by real-time quantitative RT-PCR. Values are means ± SE; n = 4–10. **P < 0.01 (by 2-way ANOVA followed by Tukey’s post test).
