Fig. 7.

Changes in inflammatory cytokine and chemokine levels with the repeated-dosing regimen of cisplatin (0 or 7 mg/kg once a week for 4 wk) in 8- and 40-wk-old male FVB mice. Tumor necrosis factor-α (Tnfa; A), interleukin-6 (Il6; B), chemokine (C-X-C motif) ligand 1 (Cxcl1; C), and monocyte chemoattractant protein 1 (Mcp1; D) were measured in the kidney cortex by real-time quantitative RT-PCR. Values are means ± SE; n = 5–10. **P < 0.01, ****P < 0.0001 (by 2-way ANOVA followed by Tukey’s post test).