Table 2.
Age and sex-adjusted characteristics of individuals across complement C3 quartiles (Q1-Q4)
| C3 quartiles | P for trend a | ||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||
| No. of subjects | 1069 | 1195 | 1145 | 1143 | – |
| Age (years) | 56.2 (55.9, 56.6) b | 57.3 (56.9, 57.6) | 57.9 (57.5, 58.2) | 57.7 (57.4, 58.1) | <0.001 |
| Sex (male, %) | 34.4 | 41.7 | 42.5 | 40.2 | <0.001 |
| Fasting glucose (mmol/L) | 4.85 (4.80, 4.90) | 4.95 (4.90, 5.00) | 5.12 (5.07, 5.17) | 5.38 (5.33, 5.44) | <0.001 |
| Systolic blood pressure (mmHg) | 136.6 (135.6, 137.6) | 138.6 (137.7, 139.6) | 142.4 (141.4, 143.5) | 143.4 (142.4, 144.4) | <0.001 |
| Diastolic blood pressure (mmHg) | 84.3 (83.8, 84.8) | 85.9 (85.4, 86.4) | 87.4 (86.9, 87.9) | 88.8 (88.3, 89.3) | <0.001 |
| Waist circumference (cm) | 78.6 (78.0, 79.1) | 82.2 (81.7, 82.7) | 85.5 (84.9, 86.0) | 90.1 (89.5, 90.7) | <0.001 |
| Low-density lipoprotein cholesterol (mmol/L) | 3.77 (3.72, 3.82) | 4.00 (3.95, 4.06) | 4.13 (4.07, 4.19) | 4.24 (4.18, 4.30) | <0.001 |
| eGFR (mL/min per 1.73 m2) | 89.0 (88.2, 89.8) | 88.1 (87.4, 88.9) | 88.8 (88.1, 89.6) | 87.6 (86.9, 88.4) | 0.04 |
| Cystatin C (mg/L) | 0.75 (0.75, 0.76) | 0.77 (0.76, 0.77) | 0.77 (0.76, 0.77) | 0.78 (0.77, 0.79) | <0.001 |
| Creatinine (μmol/L) | 84.9 (84.1, 85.7) | 85 (84.2, 85.7) | 84.1 (83.3, 84.8) | 84.4 (83.6, 85.2) | 0.11 |
| High alcohol consumption (%) | 3.37 | 3.26 | 3.84 | 3.24 | 0.99 |
| Smokers (%) | 23.9 | 23.5 | 19.0 | 20.3 | <0.001 |
| Anti-hypertensive medication (%) | 10.3 | 13.4 | 17.2 | 24.9 | <0.001 |
| Diabetes (%) | 2.90 | 4.35 | 8.03 | 15.8 | <0.001 |
| Cardiovascular disease (%) | 1.59 | 1.67 | 1.83 | 3.94 | <0.001 |
eGFR, estimated glomerular filtration rate according to the 2012 Chronic Kidney Disease Epidemiology Collaboration equation
aMultiple linear or logistic regression analysis, adjusted for age and sex
bGeometric mean (95% confidence interval) (all such values)