Table 3.
Incidence of hospitalization due to chronic kidney disease in relation to complement C3 quartiles (Q1-Q4)
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P for trend a | |
|---|---|---|---|---|---|
| C3 range (g/L) | <1.3 | 1.31–1.49 | 1.50–1.71 | >4.05 | |
| No. of subjects | 1069 | 1195 | 1145 | 1143 | – |
| Incidence (main diagnosis) b | 7 | 16 | 26 | 45 | – |
| Incidence (per 1000 person-years) | 0.33 | 0.69 | 1.20 | 2.09 | – |
| Model 1 d | Reference | 2.09 (0.86, 5.07) c | 3.63 (1.58, 8.36) | 6.46 (2.91, 14.3) | <0.001 |
| Model 2 e | Reference | 1.86 (0.77, 4.53) | 3.14 (1.36, 7.24) | 5.82 (2.62, 12.9) | <0.001 |
| Model 3 f | Reference | 1.68 (0.69, 4.13) | 2.71 (1.15, 6.39) | 3.16 (1.36, 7.34) | 0.003 |
| Incidence (main or contributing diagnosis) g | 20 | 38 | 51 | 77 | – |
| Incidence (per 1000 person-years) | 0.96 | 1.65 | 2.35 | 3.60 | – |
| Model 1 d | Reference | 1.74 (1.01, 2.98) | 2.50 (1.49, 4.19) | 3.89 (2.38, 6.37) | <0.001 |
| Model 2 e | Reference | 1.50 (0.87, 2.58) | 2.07 (1.23, 3.48) | 3.46 (2.12, 5.66) | <0.001 |
| Model 3 f | Reference | 1.39 (0.81, 2.40) | 1.50 (0.88, 2.55) | 1.73 (1.02, 2.92) | 0.047 |
aAnalysis by Cox proportional hazards model
bIncidence of hospitalization due to chronic kidney disease (defined as 585–586 according to International Classification of Diseases (ICD) 9, and N18 and N19 according to ICD10; main diagnosis refer to cases at the first position; main or contributing diagnosis refer to cases at one of the first three positions)
cAdjusted hazard ratios (95% confidence interval) (all such values)
dCrude model
eAdjusted for age and sex
fAdjusted for age, sex, waist circumference, smoking and drinking habits, low-density lipoprotein cholesterol, diabetes, cardiovascular disease, anti-hypertensive drug medication, and baseline estimated glomerular filtration rate