Fig. 2.

Chlamydia pneumoniae infection of human astrocytes alters the transcript expression of AD-related genes. Gene transcripts from Cpn-infected and uninfected cells analyzed at all four timepoints post-infection revealed significant fold changes in genes closely related to AD pathology. The fold changes of fourteen genes implicated in known pathways of AD pathology are presented in a. Histograms of fold changes of these AD-associated genes are presented in b. All expression data was normalized to β-actin and Cpn-infected and uninfected cDNA samples were repeated in biological (N = 3) and technical triplicate for each timepoint. Asterisk indicates p < 0.05. ADAM10, A disintegrin and metalloproteinase 10; APH1A, anterior pharynx defective protein 1A; APOE, apolipoprotein E; APP, amyloid precursor protein; BACE1, βAPP-cleaving enzyme 1; GSK3B, glucogen synthase kinase 3-β; IL1A, interleukin 1α; LPL, lipoprotein lipase; lipoprotein receptor-related protein 1, LRP1; MAP2, microtubule associated protein 2; MAPT, microtubule associated protein tau; NCSTN, nicastrin; PSEN1, presenilin-1, PSEN2, presenilin-2