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. 2018 Oct 26;316(1):H145–H159. doi: 10.1152/ajpheart.00029.2018

Fig. 5.

Fig. 5.

Acute pressure overload induces cardiac functional changes in mixed lineage kinase-3-deficient (MLK3−/−) mice in the absence of overt structural abnormalities. Left ventricular (LV) function was evaluated by in vivo hemodynamics in wild-type (MLK3+/+) and MLK3−/− subjected to sham or 25-gauge transverse aortic constriction (TAC) surgery for 1 wk. A: LV end-diastolic pressure (LVEDP; n = 6–8 per group). B: maximal rate of LV contractility. C: maximal rate of LV relaxation. D: systolic blood pressure (BP) measured proximal to the TAC ligature. E: LV mass normalized to tibia length. F: RNA expression of Nppa evaluated by quantitative PCR in LV tissues. Data were analyzed by two-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001.