Table 1.
Baseline organ masses in MLK3+/+ and MLK3−/− mice
| MLK3+/+ | MLK3−/− | P Value | |
|---|---|---|---|
| 12 Weeks | |||
| n | 11 | 14 | |
| LV, mg | 83.5 ± 2.6 | 99.4 ± 3.1 | <0.001 |
| HW, mg | 114.1 ± 3.2 | 127.9 ± 3.7 | 0.012 |
| Lung, mg | 145.5 ± 2.3 | 150.3 ± 6.8 | 0.48 |
| LV/TL, mg/cm | 47.1 ± 1.5 | 57.2 ± 1.8 | <0.001 |
| HW/TL, mg/cm | 64.4 ± 1.9 | 73.6 ± 2.1 | 0.004 |
| Lung/TL, mg/cm | 82.0 ± 1.3 | 86.1 ± 0.5 | 0.39 |
| BW, g | 29.3 ± 1.2 | 28.4 ± 0.8 | 0.564 |
| 24 Weeks | |||
| n | 4 | 9 | |
| LV, mg | 91.85 ± 5.32 | 106.57 ± 3.43 | 0.053 |
| HW, mg | 120.15 ± 7.88 | 138.63 ± 3.24 | 0.037 |
| Lung, mg | 182.58 ± 12.04 | 172 ± 4.85 | 0.391 |
| LV/TL, mg/cm | 50.68 ± 2.67 | 59.66 ± 2.13 | 0.045 |
| HW/TL, mg/cm | 66.29 ± 4.04 | 77.60 ± 2.08 | 0.029 |
| Lung/TL, mg/cm | 100.71 ± 6.15 | 96.27 ± 2.84 | 0.503 |
| BW, g | 39.38 ± 1.64 | 37.18 ± 1.06 | 0.316 |
Data are expressed as means ± SE. Organs from mice at 12 wk and at 24 wk of age were weighed and normalized relative to tibia length. MLK3, mixed lineage kinase-3; LV, left ventricle; HW, heart weight; TL, tibia length; BW, body weight. Data were analyzed by ANOVA.