Table 2.
Baseline cardiac structure and function in MLK3+/+ and MLK3−/− mice
| MLK3+/+ (n = 8) | MLK3−/− (n = 8) | P Value | |
|---|---|---|---|
| Ejection fraction, % | 68.4 ± 2.26 | 63.9 ± 3.01 | 0.318 |
| Fractional shortening, % | 37.8 ± 1.72 | 34.5 ± 2.17 | 0.248 |
| End-diastolic diameter, mm | 3.62 ± 0.07 | 3.73 ± 0.11 | 0.478 |
| End-systolic diameter, mm | 2.25 ± 0.08 | 2.46 ± 0.14 | 0.299 |
| Anterior wall thickness, mm | 1.06 ± 0.04 | 1.07 ± 0.04 | 0.887 |
| Posterior wall thickness, mm | 0.91 ± 0.06 | 1.03 ± 0.06 | 0.179 |
| Heart rate, beats/min | 435 ± 11.5 | 417 ± 15.0 | 0.389 |
Data are expressed as means ± SE. Echocardiographic analysis of mice was conducted before randomization for (TAC) surgery. MLK3, mixed lineage kinase-3. Data were analyzed by ANOVA.