Table 4.
Hemodynamic analysis in MLK3+/+ and MLK3−/− mice subjected to TAC for 4 wk
| Sham |
TAC |
||||
|---|---|---|---|---|---|
| MLK3+/+ (n = 6) | MLK3−/− (n = 5) | MLK3+/+ (n = 10) | MLK3−/− (n = 10) | P Value (Sham vs. TAC) | |
| LV EDP, mmHg | 4.88 ± 1.62 | 6.14 ± 2.59 | 13.3 ± 1.95 | 18.4 ± 3.17 | P = 0.0007 |
| LV dP/dtmax, mmHg/s | 8,810 ± 762 | 9,184 ± 667 | 9,072 ± 306 | 7,893 ± 579 | P = 0.384 |
| LV dP/dtmin, mmHg/s | −8,363 ± 590 | −8,534 ± 722 | −8,760 ± 228 | −7,576 ± 525 | P = 0.589 |
| SBP, mmHg | 99.1 ± 5.26 | 118.1 ± 7.98* | 158.3 ± 4.27 | 156.2 ± 4.87 | P < 0.0001 |
Data are expressed as means ± SE. Wild-type (MLK3+/+) and mixed lineage kinase-3-deficient (MLK3−/−) mice subjected to sham or 25-gauge transverse aortic constriction (TAC) surgery for 4 wk were analyzed using invasive hemodynamics. LV, left ventricle; dP/dtmax/min, impaired rate of ventricular contractility/relaxation; EDP, end-diastolic pressure; SBP, systolic blood pressure. Data were analyzed by two-way ANOVA; P values indicate comparison between sham and TAC-operated groups.
*
P < 0.05 vs. MLK3+/+ sham group.