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. 2018 Oct 31;316(1):H1–H9. doi: 10.1152/ajpheart.00145.2018

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Fig. 2. — Stimulation of coronary collateral growth. A: the work flow of experimental stimulation of coronary collateral growth (CCG). B–D: three-dimensional reconstruction of microcomputed tomography images of the vasculature in the rodent heart. B: vascular tree of a heart without the stimulation of repetitive ischemia (RI). C: artist’s rendering of vascular tree of a heart with the stimulation of RI. D: vascular tree of a heart without the stimulation during the ligation of the left anterior descending coronary artery (LAD). Note the lack of vascular perfusion in the collateral dependent zone. E: artist’s rendering of vascular tree of a heart with the stimulation during ligation of the LAD. Note repetitive ischemia stimulated growth of coronary collaterals (pink) and provides an alternate supply route, bypassing the site of LAD ligation.