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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Brain Behav Immun. 2018 Oct 26;75:208–219. doi: 10.1016/j.bbi.2018.10.009

Figure 1. Chronic-intermittent ethanol two-bottle choice paradigm.

Figure 1.

A. Schematic illustrating the chronic-intermittent ethanol two-bottle choice behavioral paradigm used to induce ethanol dependence in C57BL/6J mice. B. Average blood ethanol levels (BEL) achieved during weeks of chronic intermittent ethanol vapor exposure and terminal BEL for Dep mice. C. Ethanol intake during two-bottle choice testing, demonstrating a significant escalation in the average ethanol intake in dependent (Dep, n = 38) compared to non-dependent (Non-Dep, n = 40) mice during the last week of 2-bottle choice (inset). ##, p < 0.01 by one-tailed t-test.